OBTAINING AND PROPERTIES OF THE IMPLANT FILM MADE WITH CARBOXYMETHYLCELLULOSE CONTAINING SILVER NANOPARTICLES USED FOR TREATMENT OF BURN WOUNDS

Abstract

This article studies feasibilities of making an implant-film for treatment of burn wound, based on silver nanoparticles (AgNPs) stabilized by sodiumcarboxymethylcellulose (Na-CMC) with degrees of substitution (DS) 0.65-0.90 and polymerization (DP) 200-600 synthesized using a photochemical method. The structural, physical and chemical, and physicalmechanical, burn wound healing properties as well as antimicrobial effects of implant-films containing the Na-CMC and AgNPs have been investigated. The shape, quantity, and size of the AgNPs embedded into the Na-CMC films were determined by UV-Vis spectroscopy, dynamic light scattering (DLS), atomic force microscopy (AFM) and transmission electron microscopy (TEM). It was found that the increase of silver nitrate concentration in solution of Na-CMC followed by photoirradiation leads to changes of AgNPs size and shape. It was found out that Na-CMC films containing AgNPs in the size ranging from 5 to 35 nm had enhanced the microbicide effects and burn wound healing properties within 14 days.